HORDB

ID: hor000894
Uniprot ID: P07480(33-61)
Protein name: Galanin
Gene name: GAL
Organism: Sus scrofa (Pig)
Family: Galanin family
Source: animal
Expression: stomach
Disease: NA
Comments: NA
Taxonomy: Sus (genus), Suidae (family), Suina (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0004966 galanin receptor activity; GO:0005179 hormone activity; GO:0005184 neuropeptide hormone activity; GO:0031763 galanin receptor binding; GO:0031764 type 1 galanin receptor binding; GO:0031765 type 2 galanin receptor binding; GO:0031766 type 3 galanin receptor binding
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0045944 positive regulation of transcription by RNA polymerase II
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space; GO:0030141 secretory granule

Sequence: GWTLNSAGYLLGPHAIDNHRSFHDKYGLA
Length: 29(33-61)
Propeptide: MPRGCALLLASLLLASALSATLGLGSPVKEKRGWTLNSAGYLLGPHAIDNHRSFHDKYGLAGKRELEPEDEARPGGFDRLQSEDKAIRTIMEFLAFLHLKEAGALGRLPGLPSAASSEDAGQS
Signal peptide: MPRGCALLLASLLLASALS
Modification: T29 Alanine amide
Glycosylation: NA
Mutagenesis: NA

Function: May regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
Mechanism: NA
Cross BBB: NA
Target: GALR1, GALR3
Target Unid: A0A5G2R3V6, F1SKN3
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000894_AF2.pdb

hor000894_ESM.pdb

Mass:	371118	Formula:	C146H212N42O41
Absent amino acids:	CEMQV	Common amino acids:	GL
pI:	7.79	Basic residues:	5
Polar residues:	11	Hydrophobic residues:	10
Hydrophobicity:	-45.17	Boman Index:	-3572
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	77.59
Instability Index:	1478.62	Extinction Coefficient cystines:	8480
Absorbance 280nm:	302.86